Publications
WP1 Ecotoxicology and Toxicology
Toxicology
Park, M.V., Annema, W., Salvati, A., Lesniak, A., Elsaesser, A., Barnes, C., McKerr, G., Howard, C.V., Lynch, I., Dawson, K.A., Piersma, A.H., de Jong, W.H.
In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles.
Toxicol Appl Pharmacol. 2009, 240, 108-116.
Barnes, C.A., Elsaesser, A., Arkusz, J., Smok, A., Palus, J., Lesniak, A., Salvati, A., Hanrahan, J.P., de Jong, W.H., Dziubałtowska, E., Stępnik, M., Rydzyński, K., McKerr, G., Lynch, I., Dawson, K.A., Howard, C.V.
Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity.
Nano Lett. 2008 8, 3069-3074.
Ecotoxicology
Van Hoecke, K., Quik, J.T.K., Mankiewicz-Boczek, J., De Schamphelaere, K.A.C., Salvati, A., Lesniak, A., Rydzyński, K., Dawson, K.A., Lynch, I., Van der Meeren, P., Janssen, C.R.
Fate and effects of ceria nanoparticles in aquatic toxicity tests.
Environ. Sci. Technol. 2009, 43, 4537–4546.
WP2 Nanoparticle synthesis & Dispersion
Sperling, R.A., Liedl, T., Duhr, S., Kudera, S., Zanella, M., Lin, C.-A.J., Chang, W., Braun, D., Parak, W. J.
Size determination of (bio-) conjugated water-soluble colloidal nanoparticles - a comparison of different techniques.
J. Phys. Chem. C 2007, 111, 11552-11559.
Kreft, O., Muñoz Javier, A., Sukhorukov, G. B., Parak, W. J.
Polymer microcapsules as mobile local pH-sensors.
J. Mater. Chem. 2007, 17, 4471- 4476.
WP3 Nanoparticle-protein interactions
Lynch, I., Salvati, A., Dawson, K.A.
Protein-nanoparticle interactions: What does the cell see? Nature Nanotechnol. 2009, 4, 546-547.
Lynch, I.,
Protein-Nanoparticle interactions.
Nano Today 2008, 3, 40-47.
Protein fibrillation:
Cabaleiro-Lago C, Quinlan-Pluck F, Lynch I, Lindman S, Minogue AM, Thulin E, Walsh DM, Dawson KA, Linse S.
Inhibition of amyloid beta protein fibrillation by polymeric nanoparticles.
J Am Chem Soc. 2008 130, 15437-15443.
Linse S, Cabaleiro-Lago C, Xue W-F, Lynch I, Lindman S, Thulin E, Radford SE, Dawson KA,
Nucleation of protein fibrillation by nanoparticles.
PNAS, 2007, 104, 8691-8696.
Protein corona:
Hellstrand, E., Lynch, I., Andersson, A., Drakenberg, T., Dahlbäck, B., Dawson, K.A., Linse, S., Cedervall, T.
Complete high-density lipoproteins in nanoparticle corona. FEBS J. 2009, 276, 3372-3381.
Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson KA.
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts.
Proc Natl Acad Sci U S A. 2008, 105, 14265-14270.
Cedervall, T., Lynch, I., Foy, M., Berggard, T., Donnelly, S.C., Cagney, G., Linse, S., Dawson, K.A.
Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles.
Angew Chem Int Ed Engl. 2007, 46, 5754-5756.
Lynch, I.
Are there Generic Mechanisms Governing Interactions between Nanoparticles and Cells? Random Epitope Mapping For the outer layer of the Protein-material Interface.
Physica A, 2007, 373, 511-520.
Cedervall T, Lynch I, Lindman S, Berggård T, Thulin E, Nilsson, H, Linse S, Dawson KA. Understanding the nanoparticle protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.
PNAS, 2007, 104, 2050-2055.
Klein, J.
Probing the interactions of proteins and nanoparticles
PNAS, 2007,104, 2029–2030.
WP4 Spatiotemporal aspects of nanoparticle-cell interactions
Muñoz_Javier, A., Kreft, O., Semmling, M., Kempter, S., Skirtach, A.G., Bruns, O., del Pino, P., Bedard, M.F., Rädler, J.O., Käs, J., Plank, C., Sukhorukov, G.B., Parak, W.J.
Uptake of colloidal polyelectrolyte coated particles and polyelectrolyte multilayer capsules by living cells
Advanced Materials, 2008, 20, 4281-4287
Semmling, M., Kreft, O., Muñoz Javier, A., Sukhorukov, G.B., Käs, J., Parak, W.J.
A novel flow cytometry based assay for cellular uptake studies of polyelectrolyte microcapsules.
SMALL, 2008, 4, 1763-1768.
Jiang, L., Titmuss, S., Cowley, A., Klein, J.
Enantioselectivity of Hyaluronan: preferential interactions with chiral surfaces.
Soft Matter, 2008, 4, 1521–1530.
Williams, Y., Byrne, S., Whelan, A., Bashir, M, Davies, A., Gun’ko, Y., Kelleher, D., Volkov, Y.
Comparison of three cell fixation methods for high content analysis assays utilizing quantum dots.
J. Microscopy, 2008, 232, 91-98.
Conroy, J., Byrne, S.J., Gun’ko, Y.K., Rakovich, Y.P., Donegan, J.F., Davies, A., Kelleher, D., Volkov, Y.
CdTe nanoparticles display tropism to core histones and histone rich cell organelles.
Small, 2008 4, 2006-2015.
Lin, C.J., Liedl, T., Sperling, R.A., Fernández-Argüelles, M.T., Costa-Fernández, J.M., Pereiro, R., Sanz-Medel, A., Chang, W.H., Parak, W.J.
Bioanalytics and Biolabeling with Semiconductor Nanoparticles (Quantum Dots).
J. Mater. Chem. 2007, 17, 1343-1346.
Nabiev, I., Mitchell, S., Davies, A., Williams, Y., Kelleher, D.,
Nonfunctionalized Nanocrystals Can Exploit a Cell's Active Transport Machinery Delivering Them to Specific Nuclear and Cytoplasmic Compartments.
Nano Lett., 2007, 7, 3452 -3461.
Luccardini, C., Yakovlev, A., Gaillard, S., van‘t Hoff, M., Piera Alberola, A., Mallet, J.-M., Parak, W.J., Feltz, A., Oheim, M.
Getting across the plasma membrane and beyond: intracellular uses of colloidal semiconductor nanocrystals.
J. Biomed. Biotechnol. 2007, article ID 68963.
WP5 – Functional Impacts of nanoparticles
Correlation signature of the macroscopic states of the gene regulatory network in cancer.
PNAS, 2009, 106, 4079-4084.
Dawson KA, Salvati A, Lynch I.
Nanotoxicology: nanoparticles reconstruct lipids.
Nature Nanotechnol. 2009 4, 84-85.
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